The promise of pharmacoepidemiology in helping clinicians assess drug risk.

Latest drug safety alerts from the 27th International Conference on Pharmacoepidemiology and Therapeutic Risk Management.

Pharmacoepidemiology, Adverse and Beneficial Effects

Pharmacoepidemiology has been defined as “the study of the distribution and determinants of drugrelated events in populations and the application of this study to efficacious drug treatment” [26]. Similar definitions have been given by several authors [37, 53]. The term “drug” in the definition is generally understood to include biologics, such as vaccines, and the populations are understood to...

Relevance of pharmacoepidemiology to Nepal.

Drug-related problems such as overuse of injectable drug products and antimicrobials, increased cost of drug therapy, polypharmacy, and adverse drug reactions (ADRs) are prevalent in the healthcare settings of Nepal. To date, no new drug development processes or clinical trials have been conducted in Nepal, despite the fact that studies of real life situations are an essential tool for monitori...

Principles of Epidemiology for Clinical and Formulary Management Professionals

management to make decisions that are clinically justified and economically prudent. Epidemiology is concerned primarily with the distribution and determinants of the frequency of disease in populations.1 Thanks in large part to epidemiology, the middle of the 20th century saw many great advances in public health, such as the Framingham Heart Study,2 identifying the association between cigarett...

The effect of beta-blocker therapy on quality of life in heart failure patients: a systematic review and meta-analysis.

PURPOSE To assess the impact of beta-blocker therapy on quality of life (QoL) in chronic heart failure (CHF) patients receiving optimal standard medication. METHODS Randomised controlled trials (RCT) assessing QoL with a generic or disease specific instrument were identified by searching Medline, Embase, Pascal, Cochrane Controlled Trial database, and the bibliographies of the published artic...